打了昂贵的生物制剂还是没效?你差的可能是一把“细菌钥匙”
你有没有听过身边炎症性肠病(IBD,包括克罗恩病和溃疡性结肠炎)患者的绝望?打上了昂贵的“生物制剂”(抗TNF抗体,如英夫利西单抗、阿达木单抗),满怀希望,但几周甚至几个月后,医生无奈地摇头:效果不好,或者刚开始有效,后来就没用了。
《科学》(20220325出版)一周论文导读
Thermoelectric materials allow for direct conversion between heat and electricity, offering the potential for power generation. The average dimensionless figure of merit ZTave determines device efficiency. N-type tin selenide crystals exhibit outstanding three-dimensional charge and two-dimensional phonon transport along the out-of-plane direction, contributing to a high maximum figure of merit Zmax of ~3.6 × 10−3 per kelvin but a moderate ZTave of ~1.1. We found an attractive high Zmax of ~4.1 × 10−3 per kelvin at 748 kelvin and a ZTave of ~1.7 at 300 to 773 kelvin in chlorine-doped and lead-alloyed tin selenide crystals by phonon-electron decoupling. The chlorine-induced low deformation potential improved the carrier mobility. The lead-induced mass and strain fluctuations reduced the lattice thermal conductivity. Phonon-electron decoupling plays a critical role to achieve high-performance thermoelectrics.
红警磁爆线圈是特斯拉的发明?今天聊聊能炸天的无线输电
【太平洋汽车网 技术频道】众所周知,修行尚浅的老僧无法“隔衣疗伤”,传授内力更是只能通过肌肤接触的方式传功。与武侠世界中相似的是,现实生活中的接触式能量传输之效率同样远高于隔空传输,听到这就连水果铁粉都想把贵上天的Magsafe磁贴定义为百无一用的宗教圣器。
《自然》(20200116出版)一周论文导读
AbstractCoralreef fishes are predicted to be especially susceptible to end-of-century ocean acidification on the basis of several high-profi
声波谐振器助力5G高性能射频滤波器发展
滤波器是一种选频装置,通过耦合基本元件或谐振器来实现,可以使信号中特定的频率成分通过,而极大地衰减其它频率成分。
【复材资讯】晶界,Nature!
研究背景在广泛的条件下(温度、压力、应变速率等),金属和合金的永久性或塑性变形是通过位错实现的,这些线性缺陷的存在和移动决定了晶体材料的力学行为。金属通常以多晶形式存在,其中每个晶体区域或晶粒由晶界分隔,而晶界是位错运动的已知障碍。
软件度量指标(架构指标)
指标如同系统中的一个开关,如果你打开它,系统可能会有不同的反应。找到合适的指标让系统达到预期效果很不容易。然而,弃之不顾不是明智之举。软件架构健康度优化常比喻为医生诊断疾病。指标度量非常重要,但不等同于医生的诊断。开发团队的专业知识和经验也至关重要。
《科学》(20211126出版)一周论文导读
Twisting monolayers of graphene with respect to each other has led to a number of unusual correlated states. This approach has inspired researchers to try their hand at twisting two-dimensional magnets, but such experiments have proven a difficult challenge. Song et al. made structures out of layers of the 2D magnet chromium triiodide with a small twist angle . Using nitrogen vacancy centers in diamond as a magnetometer, the authors imaged the magnetic domains in both twisted monolayer and twisted trilayer structures. For twisted trilayers, a periodic pattern of ferromagnetic and antiferromagnetic domains was revealed.